Patrick K. Albers
I focus on studying the evolutionary history of genetic variation in the human genome, as it is of considerable relevance for complex disease research. Much of this interest derives from several aspects; (a) the recent technological advances which allow to study human genetic information in unprecedented detail, (b) the understanding that low frequency variants may play a significant role in disease susceptibility, (c) the appreciation that genes involved in the aetiology of a genetic disorder are likely to carry non-neutral evolutionary signatures, and (d) the fact that rare variants accumulated in recent evolutionary times in the human genome, marking them as informative for both population genetics and human disease research. My interest concerns rare genetic variation and its impact on complex disease. I want to integrate population genetic analyses with applications in disease-association of rare variants.
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